Notable Alums


Specialty: Cardiology

Graduation Year: 1977

William O’Neill

William O’Neill, M.D. ’77, is an internationally recognized leader in interventional cardiology at Henry Ford Hospital’s Center for Structural Heart Disease in Detroit. He is board certified in Internal Medicine and Cardiovascular Disease.

Dr. O’Neill completed a residency at the WSU School of Medicine and a fellowship at the University of Michigan Hospital. He continued at UM, becoming director of the Cardiac Catheterization Laboratory and associate professor of Medicine, before joining William Beaumont Hospital as director of the Division of Cardiovascular Medicine.

In 2006, he left Michigan for the University of Miami Miller School of Medicine as executive dean for Research, Research Training and Innovative Medicine, and later as chief executive officer for Research. In 2012, he returned to Detroit, joining Henry Ford Hospital as medical director of its new Center for Structural Heart Disease, focusing on new minimally invasive treatments for heart failure and heart valve disease.

Dr. O’Neill cowrote the first randomized trial of intracoronary streptokinase therapy for acute myocardial infarction, and initiated the first randomized trial of balloon angioplasty. He also pioneered balloon valvuloplasty for aortic and mitral stenosis, and outpatient angioplasty, and was involved in the largest international interventional study ever to develop a new oral glycoprotein IIb/IIIa antagonist.

He was a founding member of the American Board of Internal Medicine’s Interventional Cardiology Board, which certifies all interventional cardiologists, and the founding chair of the Innovation in Intervention Summit of the American College of Cardiology. He has served on the American Board of Internal Medicine Subspecialty Board of Interventional Cardiology and the Scientific Program Committee of the American College of Cardiology.

Dr. O’Neill is an author of more than 300 hundred peer-reviewed articles and abstracts, has written multiple book chapters, and edited one of the first textbooks in the field of interventional cardiology.

In 1999, he received the WSU School of Medicine Alumni Association’s Distinguished Alumni Award. His other honors include the Transcatheter Cardiovascular Therapeutics Lifetime Achievement Award and the Seymour Gordon Award for Distinguished Achievement, Michigan Chapter, American Heart Association. He served on the WSU School of Medicine’s Board of Visitors and was president of the Alumni Board of Governors